Dose-Response Analysis of Multiple Experiments

You can see how your data is affected in the preview page 'Data Set'.
* = Required fields. The additional identifier is optional, if this information is available.
Note that the four options do not result in different estimated values. The selected name is used in results tables and plots.
e.g., enter 50 for estimation of EC50/IC50/ED50/ID50.
e.g., the maximum change of mean observed effect is less than 40% (0.4).
Restriction on 4-parameter log-logistic curve:



v1.0 12.11.2014
Author: Xiaoqi Jiang

WebApp MDRA

is a web application for performing dose-response analysis of multiple experiments.


- Application of the four-parameter log-logistic model to fit dose-response data.

- Visualization of dose-response data containing multiple experiments by applying DORES (dose-response screening) plot.

For details about DORES plot, see: Jiang, Xiaoqi, and Annette Kopp-Schneider. Statistical strategies for averaging EC50 from multiple dose-response experiments. Archives of Toxicology. (2014)

- Application of the meta-analysis approach to performing averaging analysis of dose-response data from multiple experiments.

For details, see: Jiang, Xiaoqi, and Annette Kopp-Schneider. Summarizing EC50 estimates from multiple dose-response experiments: A comparison of a meta-analysis strategy to a mixed-effects model approach. Biometrical Journal. 56(3): 493-512 (2014).


The browsers Chrome and Firefox are recommended for users!

- Download User Guide
- Download Example Data


For help, please use the contact form or email kopp (at) dkfz-heidelberg.de

Exclusion of 'no effect' experiments from averaging analysis:









Download DORES Plot is saved as PDF-file for download
Results Table Download The following result table is saved as CSV-file for download
Single Curve Download The dose-response curve plotted for each single experimental data is saved as PDF-file for download

Forest plot








Download DORES Plot is saved as PDF-file for download